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overview Dr. Chang specializes in renal pathology. He joined the Department of Pathology at the University of Chicago in 2004 and is now a Professor. He was Past-President of the Renal Pathology Society (2017) and Chicago Pathology Society (2011-2013). He has taught more than 30 educational courses at the annual meetings for the American Society Clinical Pathology, College of American Pathologists, US & Canadian Academy of Pathology, American Society of Nephrology, American College of Rheumatology, and American Urological Association. His research interests include the role of B and plasma cells in lupus nephritis and transplant rejection. He is on the editorial board of Laboratory Investigation and Archives of Pathology and Laboratory Medicine. He has authored over 100 peer-reviewed papers, reviews, and book chapters, including the Kidney chapter for Robbins and Cotran: Pathologic Basis of Disease. He is the co-editor of the 2nd edition of the “Diagnostic Pathology: Transplant Pathology” textbook and co-editor for the 3rd edition of “Diagnostic Pathology: Kidney Diseases.”
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Item TypeName
Concept Alleles
Concept Amino Acid Sequence
Concept Anti-Inflammatory Agents, Non-Steroidal
Concept Serum Amyloid A Protein
Concept Arteriovenous Shunt, Surgical
Concept Base Sequence
Concept Blood Urea Nitrogen
Concept Carcinoma, Non-Small-Cell Lung
Concept Complement System Proteins
Concept United Kingdom
Concept Hearing Loss, Sensorineural
Concept Drug Synergism
Concept Decision Support Techniques
Concept Glomerulosclerosis, Focal Segmental
Concept Graft Survival
Concept Cardiac Surgical Procedures
Concept Cross-Sectional Studies
Concept Disease Susceptibility
Concept Muscle, Smooth
Concept Feasibility Studies
Concept Nephrotic Syndrome
Concept Particle Size
Concept Molecular Sequence Data
Concept Myelodysplastic Syndromes
Concept Neoplasm Staging
Concept Serum Sickness
Concept Receptors, Cell Surface
Concept Solutions
Concept Cohort Studies
Concept Saline Solution, Hypertonic
Concept Sensitivity and Specificity
Concept Mass Spectrometry
Concept Swine
Concept Sheep
Concept Sickle Cell Trait
Concept Societies, Medical
Concept Syndactyly
Concept Stress, Mechanical
Concept Spectrum Analysis, Raman
Concept Stem Cells
Concept United States
Concept Hematopoietic Stem Cell Transplantation
Concept Up-Regulation
Concept B-Lymphocyte Subsets
Concept Lupus Erythematosus, Systemic
Concept Chi-Square Distribution
Concept Drug Delivery Systems
Concept Case-Control Studies
Concept T-Lymphocyte Subsets
Concept Sus scrofa
Concept In Situ Hybridization
Concept Sepsis
Concept Pathology, Surgical
Concept Single-Cell Analysis
Concept Intercellular Signaling Peptides and Proteins
Concept Lupus Vasculitis, Central Nervous System
Concept Renin-Angiotensin System
Concept Surveys and Questionnaires
Concept Serum Albumin
Concept Severity of Illness Index
Concept Sampling Studies
Concept Specimen Handling
Concept Sulfonamides
Concept Mesenchymal Stem Cell Transplantation
Concept Spleen
Concept Suspensions
Concept Survival Analysis
Concept Ureter
Concept Survival Rate
Concept Patient Selection
Concept Spectroscopy, Near-Infrared
Concept Urothelium
Concept Health Care Surveys
Concept Transcriptome
Concept Syndecan-1
Concept RNA, Small Interfering
Concept Intracellular Signaling Peptides and Proteins
Concept National Heart, Lung, and Blood Institute (U.S.)
Concept Anemia, Sickle Cell
Concept Cell Survival
Concept Follow-Up Studies
Concept Hepatorenal Syndrome
Concept Longitudinal Studies
Concept Mice, Mutant Strains
Concept Prospective Studies
Concept Retrospective Studies
Concept Seizures
Concept Staining and Labeling
Concept Ureteral Obstruction
Concept Signal Transduction
Concept Mice, SCID
Concept Hidradenitis Suppurativa
Academic Article Mouse podocyte complement factor H: the functional analog to human complement receptor 1.
Academic Article Expanding the pathologic spectrum of light chain deposition disease: a rare variant with clinical follow-up of 7 years.
Academic Article A rare cause of necrotizing and crescentic glomerulonephritis in a young adult male.
Academic Article Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease.
Academic Article Unrestricted C3 activation occurs in Crry-deficient kidneys and rapidly leads to chronic renal failure.
Academic Article Nephron segment localization of polyoma virus large T antigen in renal allografts.
Academic Article Pauci-immune and immune glomerular lesions in kidney transplants for systemic lupus erythematosus.
Academic Article Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells.
Academic Article Nonneoplastic kidney diseases in adult tumor nephrectomy and nephroureterectomy specimens: common, harmful, yet underappreciated.
Academic Article Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes.
Academic Article Microparticulate ice slurry for renal hypothermia: laparoscopic partial nephrectomy in a porcine model.
Academic Article Vitamin D receptor attenuates renal fibrosis by suppressing the renin-angiotensin system.
Academic Article IgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus.
Academic Article In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis.
Academic Article Rare association of chronic lymphocytic leukemia/small lymphocytic lymphoma, ANCAs, and pauci-immune crescentic glomerulonephritis.
Academic Article Intragraft vascular occlusive sickle crisis with early renal allograft loss in occult sickle cell trait.
Academic Article Histopathological predictors of renal function decrease after laparoscopic radical nephrectomy.
Academic Article The renal failure that vanished.
Academic Article Giant cell tubulitis with tubular basement membrane immune deposits: a report of two cases after cardiac valve replacement surgery.
Academic Article Spectrum of renal pathology in hematopoietic cell transplantation: a series of 20 patients and review of the literature.
Academic Article Non-neoplastic renal diseases are often unrecognized in adult tumor nephrectomy specimens: a review of 246 cases.
Academic Article A position paper on standardizing the nonneoplastic kidney biopsy report.
Academic Article Plasma cell densities and glomerular filtration rates predict renal allograft outcomes following acute rejection.
Academic Article Chronic kidney disease induced in mice by reversible unilateral ureteral obstruction is dependent on genetic background.
Academic Article Laparoscopic nephron-sparing surgery in the management of angiomyolipoma: a single center experience.
Academic Article Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF.
Academic Article Abnormal immune complex processing and spontaneous glomerulonephritis in complement factor H-deficient mice with human complement receptor 1 on erythrocytes.
Academic Article Membranous glomerulopathy with spherules: an uncommon variant with obscure pathogenesis.
Academic Article A position paper on standardizing the nonneoplastic kidney biopsy report.
Academic Article The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice.
Academic Article Clinical and histologic predictors of renal function decline after laparoscopic partial nephrectomy.
Academic Article The outcome of abstracts presented at the United States and Canadian Academy of Pathology annual meetings.
Academic Article Transgenic overexpression of GLUT1 in mouse glomeruli produces renal disease resembling diabetic glomerulosclerosis.
Academic Article Renal FcRn reclaims albumin but facilitates elimination of IgG.
Academic Article Thrombotic microangiopathy and peritubular capillary C4d expression in renal allograft biopsies.
Academic Article Predicting outcomes of lupus nephritis with tubulointerstitial inflammation and scarring.
Academic Article A spectrum of morphologic lesions of focal segmental glomerulosclerosis by Columbia criteria in human immunodeficiency virus infection.
Academic Article Lineage-specific identification of nonhematopoietic neoplasms by flow cytometry.
Academic Article So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity.
Academic Article Four-color flow cytometry shows strong concordance with bone marrow morphology and cytogenetics in the evaluation for myelodysplasia.
Academic Article A clinicopathologic study of thrombotic microangiopathy in the setting of IgA nephropathy.
Academic Article Protocol for the examination of specimens from patients with invasive carcinoma of renal tubular origin.
Academic Article Curcumin alleviates immune-complex-mediated glomerulonephritis in factor-H-deficient mice.
Academic Article Vitamin D receptor signaling in podocytes protects against diabetic nephropathy.
Academic Article Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction.
Academic Article Auramine orange stain with fluorescence microscopy is a rapid and sensitive technique for the detection of cervical lymphadenitis due to mycobacterial infection using fine needle aspiration cytology: a case series.
Academic Article A study of interobserver reproducibility of morphologic lesions of focal segmental glomerulosclerosis.
Academic Article Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue.
Academic Article Contrasting effects of systemic monocyte/macrophage and CD4+ T cell depletion in a reversible ureteral obstruction mouse model of chronic kidney disease.
Academic Article Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis.
Academic Article Characterization and outcomes of renal leukocyte chemotactic factor 2-associated amyloidosis.
Academic Article TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis.
Academic Article Pathologic spectrum of cysts in end-stage kidneys: possible precursors to renal neoplasia.
Academic Article The emerging role of the inflammasome in kidney diseases.
Academic Article Medullary peritubular capillary thrombi: a harbinger of sickle cell nephropathy.
Academic Article M2 macrophage infiltrates in the early stages of ANCA-associated pauci-immune necrotizing GN.
Academic Article Membranous nephropathy transplanted in the donor kidney: observations of resolving glomerulopathy in serial allograft biopsies.
Academic Article Pauci-immune glomerulonephritis in children: a clinicopathologic study of 21 patients.
Academic Article CD11b is protective in complement-mediated immune complex glomerulonephritis.
Academic Article Longitudinal changes in MRI markers in a reversible unilateral ureteral obstruction mouse model: preliminary experience.
Academic Article Response to Heyman et al. and Bredewold et al.
Academic Article Morphometric and histological parameters in veins of diabetic patients undergoing brachiocephalic fistula placement.
Academic Article The Pathogenesis and Therapeutic Implications of Tubulointerstitial Inflammation in Human Lupus Nephritis.
Academic Article Mayo Clinic/Renal Pathology Society Consensus Report on Pathologic Classification, Diagnosis, and Reporting of GN.
Academic Article Medullary Microvascular Thrombosis and Injury in Sickle Hemoglobin C Disease.
Academic Article Raman spectroscopy as a diagnostic tool for monitoring acute nephritis.
Academic Article Diagnosis in Pediatric Transplant Biopsies.
Academic Article "Urine" the "Medulla" of the Kidney: Concentrate!
Academic Article Reproducibility of the NEPTUNE descriptor-based scoring system on whole-slide images and histologic and ultrastructural digital images.
Academic Article Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography.
Academic Article The Nephrologist's Tumor: Basic Biology and Management of Renal Cell Carcinoma.
Academic Article Increased Survival for Patients With Cirrhosis and Organ Failure in Liver Intensive Care and Validation of the Chronic Liver Failure-Sequential Organ Failure Scoring System.
Academic Article Bcl-2 as a Therapeutic Target in Human Tubulointerstitial Inflammation.
Academic Article A proposal for standardized grading of chronic changes in native kidney biopsy specimens.
Academic Article Variability in assessing for BK viremia: whole blood is not reliable and plasma is not above reproach - a retrospective analysis.
Academic Article Renal allograft granulomatous interstitial nephritis: observations of an uncommon injury pattern in 22 transplant recipients.
Academic Article Renal Mass and Localized Renal Cancer: AUA Guideline.
Academic Article Kidney Transplant Outcomes in 2 Adults With Down Syndrome.
Academic Article Medical renal diseases are frequent but often unrecognized in adult autopsies.
Academic Article Collapsing Glomerulopathy in Lambda Light Chain Amyloidosis: A Report of 2 Cases.
Academic Article Quantifying in situ adaptive immune cell cognate interactions in humans.
Academic Article Renal Vasculitis and Pauci-immune Glomerulonephritis Associated With Immune Checkpoint Inhibitors.
Academic Article The Banff Working Group Classification of Definitive Polyomavirus Nephropathy: Morphologic Definitions and Clinical Correlations.
Academic Article Bim suppresses the development of SLE by limiting myeloid inflammatory responses.
Academic Article WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion.
Academic Article Extreme Renal Pathology in Alagille Syndrome.
Academic Article Chronic Microangiopathy Due to DCR-MYC, a Myc-Targeted Short Interfering RNA.
Academic Article End-Stage Kidney Disease Is Overlooked as a Proximate Cause of Death at Autopsy.
Academic Article The Importance of Nephropathology in Kidney Cancer.
Academic Article Double negative T cells, a potential biomarker for systemic lupus erythematosus.
Academic Article Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation.
Academic Article Cellular aspects of the pathogenesis of lupus nephritis.
Academic Article Arterial Intimal Fibrosis in Reperfusion Biopsy Correlates with Graft Function after Kidney Transplant.
Academic Article Discordance between immunofluorescence and immunohistochemistry C4d staining and outcomes following heart transplantation.
Academic Article Local complement factor H protects kidney endothelial cell structure and function.
Academic Article Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection.
Academic Article Extraglomerular immune complex deposition in lupus nephritis.
Academic Article Specific in situ inflammatory states associate with progression to renal failure in lupus nephritis.
Concept Health Information Systems
Concept Myeloid Cell Leukemia Sequence 1 Protein
Academic Article The Detrimental Impact of End-Stage Kidney Disease Is Not Reflected in Autopsy Reports.
Academic Article An International Survey of Genitourinary and Renal Pathologists Regarding Evaluation of the Non-Neoplastic Parenchyma in Kidney Cancer Specimens.
Academic Article A New Paradigm for Renal Thrombotic Microangiopathy.
Academic Article Mechanisms for progenitor cell-mediated repair for ischemic heart injury.
Academic Article Podocyte injury at young age causes premature senescence and worsens glomerular aging.
Academic Article Arterial pulse wave analysis: An accurate means of determining cardiac output in children.
Academic Article Neonates with congenital cardiac defects and pulmonary hypertension.
Academic Article Toward unreasonable effectiveness of cardiac ICU data: artificial intelligence in pediatric cardiac intensive care.
Academic Article Report of the National Heart, Lung, and Blood Institute Working Group: An Integrated Network for Congenital Heart Disease Research.
Academic Article Artificial intelligence in pediatric cardiology and cardiac surgery: Irrational hype or paradigm shift?
Academic Article Standardized reporting of monoclonal immunoglobulin-associated renal diseases: recommendations from a Mayo Clinic/Renal Pathology Society Working Group.
Academic Article Molecular architecture of proliferative lupus nephritis as elucidated using 50-plex imaging mass cytometry proteomics.
Academic Article Pulmonary insufficiency: preparing the patient with ventricular dysfunction for surgery.
Academic Article Adults undergoing cardiac surgery at a children's hospital: an analysis of perioperative morbidity.
Academic Article Prevention of metabolic decompensation in an infant with mutase deficient methylmalonic aciduria undergoing cardiopulmonary bypass.
Academic Article Complement and Renal Thrombotic Microangiopathy Associated With Hypertension and Scleroderma.
Academic Article HealtheDataLab - a cloud computing solution for data science and advanced analytics in healthcare with application to predicting multi-center pediatric readmissions.
Academic Article Exercise alleviates symptoms of CNS lupus.
Academic Article Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome.
Academic Article A noninvasive estimation of mixed venous oxygen saturation using near-infrared spectroscopy by cerebral oximetry in pediatric cardiac surgery patients.
Academic Article Intraoperative Hemodynamic Instability and Diagnosis of Pheochromocytoma During Excision of Adrenal Incidentaloma With Incomplete Workup: A Case Report.
Academic Article Differential expression of parietal epithelial cell and podocyte extracellular matrix proteins in focal segmental glomerulosclerosis and diabetic nephropathy.
Academic Article Hemodynamics and cerebral oxygenation following repair of tetralogy of Fallot: the effects of converting from positive pressure ventilation to spontaneous breathing.
Academic Article Upregulated PD-1 signaling antagonizes glomerular health in aged kidneys and disease.
Academic Article Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span.
Academic Article Pseudo-spectral angle mapping for automated pixel-level analysis of highly multiplexed tissue image data.
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